Pfizer says new studies show higher dose of Lipitor slows atherosclerosis
26 Mar 2007
LONDON (AFX) - Pfizer Inc said results from two new imaging trials show a higher dose of its cholesterol-fighting drug Lipitor stopped the progression of atherosclerosis in patients with coronary heart disease or familial hypercholesterolemia (FH).
The results are part of three, two-year clinical trials, involving over 2,800 patients, designed to investigate the efficacy of torcetrapib in combination with Lipitor compared to Lipitor alone.
Read the full report from here @ Forbes
Tuesday, March 27, 2007
ACC: Atherosclerosis Impervious to HDL Infusions
ACC: Atherosclerosis Impervious to HDL Infusions
By Crystal Phend, Staff Writer, MedPage Today
March 26, 2007
NEW ORLEANS, March 26 -- Artificially boosting high-density lipoprotein (HDL) levels does not reverse atherosclerosis, though it may have some vascular benefit, said researchers here.
In the ERASE trial of 183 patients with recent acute coronary syndromes, weekly infusions of CSL-111, an investigational agent made with reconstituted HDL from human plasma, showed no significant advantage over placebo in reducing plaque volumes...
However, there were significant improvements in atheroma volume versus baseline with the agent as well as in plaque characteristics and coronary scores versus placebo "strongly suggestive of rapid beneficial effects" ...
Read the full news report here @ The Med Page
By Crystal Phend, Staff Writer, MedPage Today
March 26, 2007
NEW ORLEANS, March 26 -- Artificially boosting high-density lipoprotein (HDL) levels does not reverse atherosclerosis, though it may have some vascular benefit, said researchers here.
In the ERASE trial of 183 patients with recent acute coronary syndromes, weekly infusions of CSL-111, an investigational agent made with reconstituted HDL from human plasma, showed no significant advantage over placebo in reducing plaque volumes...
However, there were significant improvements in atheroma volume versus baseline with the agent as well as in plaque characteristics and coronary scores versus placebo "strongly suggestive of rapid beneficial effects" ...
Read the full news report here @ The Med Page
Crestor Effective at Halting Early Atherosclerosis
Crestor Effective at Halting Early Atherosclerosis
This press release issued by Eurekalert says that an international study using ultrasound technology has found that the most potent cholesterol-lowering drug is also effective at halting early changes in the blood vessels that can lead to atherosclerosis.
Results from the study were reported at the annual meeting of the American College of Cardiology in New Orleans and were published on-line by the Journal of the American Medical Association. The research involved people with moderately elevated cholesterol levels who didn't qualify for treatment under national guidelines.
Read the full news report from the Hindu
This press release issued by Eurekalert says that an international study using ultrasound technology has found that the most potent cholesterol-lowering drug is also effective at halting early changes in the blood vessels that can lead to atherosclerosis.
Results from the study were reported at the annual meeting of the American College of Cardiology in New Orleans and were published on-line by the Journal of the American Medical Association. The research involved people with moderately elevated cholesterol levels who didn't qualify for treatment under national guidelines.
Read the full news report from the Hindu
Detecting Artery Disease In Your Legs - PAD
Detecting Artery Disease In Your Legs - PAD
March 23, 2007
New research finds it's in your legs not your chest that some of the most subtle signs of cardiovascular disease can appear.
The condition is called peripheral arterial disease, or PAD.
PAD affects about 10 million people in the United States. In its early stages, there may be no symptoms. Doctors say to be alert to any pain in the legs while walking that goes away when you rest. Other symptoms include swelling or numbness in the leg, sores that won't heal, or a change in the color of your leg.
Those at highest risk for PAD include anyone over age 50, people with a family history of cardiovascular disease, and anyone with diabetes, high blood pressure, or high cholesterol.
Read the full report from here @ Click on Detroit
March 23, 2007
New research finds it's in your legs not your chest that some of the most subtle signs of cardiovascular disease can appear.
The condition is called peripheral arterial disease, or PAD.
PAD affects about 10 million people in the United States. In its early stages, there may be no symptoms. Doctors say to be alert to any pain in the legs while walking that goes away when you rest. Other symptoms include swelling or numbness in the leg, sores that won't heal, or a change in the color of your leg.
Those at highest risk for PAD include anyone over age 50, people with a family history of cardiovascular disease, and anyone with diabetes, high blood pressure, or high cholesterol.
Read the full report from here @ Click on Detroit
Peripheral Vascular Disease: Keeping the Blood Flowing
Peripheral Vascular Disease: Keeping the Blood Flowing
09 March 2007, By Steve Tokar
Peripheral arterial disease (PAD) can result in “big trouble, and eventually lead to gangrene and amputation.” But not for all patients: Some grow new arteries when the old artery is blocked. Others do not, though, “and those are the ones who get into trouble.”
The problem, according to a surgeon, is that no one knows a reason for the difference. “We’ve come up with a lot of treatments for cleaning up, scraping out and bypassing arteries without really understanding why some patients have a poor response to PAD.”
Read the full report here @ UCSF
09 March 2007, By Steve Tokar
Peripheral arterial disease (PAD) can result in “big trouble, and eventually lead to gangrene and amputation.” But not for all patients: Some grow new arteries when the old artery is blocked. Others do not, though, “and those are the ones who get into trouble.”
The problem, according to a surgeon, is that no one knows a reason for the difference. “We’ve come up with a lot of treatments for cleaning up, scraping out and bypassing arteries without really understanding why some patients have a poor response to PAD.”
Read the full report here @ UCSF
Stents Prevent Peripheral Arterial Disease-Related Amputation
Stents Prevent Peripheral Arterial Disease-Related Amputation
By Crystal Phend, Staff Writer, MedPage Today
March 07, 2007
SEATTLE, March 7 -- Angioplasty and stenting of small vessels below the knee are successfully staving off amputation among older patients with severe peripheral arterial disease (PAD), researchers said here.
In a survey among 57 patients at the critical limb ischemia stage of PAD, 92% avoided amputation through two years of follow-up with the treatment, said Nael Saad, M.B., B.Ch., of the University of Rochester (N.Y.) Medical Center.
Read the full report here @ Med Page Today
By Crystal Phend, Staff Writer, MedPage Today
March 07, 2007
SEATTLE, March 7 -- Angioplasty and stenting of small vessels below the knee are successfully staving off amputation among older patients with severe peripheral arterial disease (PAD), researchers said here.
In a survey among 57 patients at the critical limb ischemia stage of PAD, 92% avoided amputation through two years of follow-up with the treatment, said Nael Saad, M.B., B.Ch., of the University of Rochester (N.Y.) Medical Center.
Read the full report here @ Med Page Today
Atherothrombosis Associated With High Rates Of Cardiovascular Events
Atherothrombosis Associated With High Rates Of Cardiovascular Events Within 1 Year
26 Mar 2007
Patients with arterial disease have relatively high rates of experiencing a cardiovascular event (such as heart attack, stroke or cardiovascular death) within one year, and these increase with the number of arterial locations afflicted, according to a large, international study in JAMA.
Read the full news story from here @ Medical News Today
26 Mar 2007
Patients with arterial disease have relatively high rates of experiencing a cardiovascular event (such as heart attack, stroke or cardiovascular death) within one year, and these increase with the number of arterial locations afflicted, according to a large, international study in JAMA.
Read the full news story from here @ Medical News Today
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